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Skin Bleaching Among African and Afro-Caribbean Women in New York City: Primary Findings from a P30 Pilot Study

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Benn, Emma K.T. Deshpande, Richa Dotson-Newman, Ogonnaya Gordon, Sharon Scott, Marian Amarasiriwardena, Chitra Khan, Ikhlas A. Wang, Yan Hong Alexis, Andrew Kaufman, Bridget Moran, Hector Wen, Chi Charles, Christopher A.D. Younger, Novie O.M. Mohamed, Nihal Liu, Bian

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2019 by the authors. Licensee MDPI, Basel, Switzerland. Coinciding with the increase in sequenced bacteria, mining of bacterial genomes for biosynthetic gene clusters (BGCs) has become a critical component of natural product discovery. The order Myxococcales, a reputable source of biologically active secondary metabolites, spans three suborders which all include natural product producing representatives. Utilizing the BiG-SCAPE-CORASON platform to generate a sequence similarity network that contains 994 BGCs from 36 sequenced myxobacteria deposited in the antiSMASH database, a total of 843 BGCs with lower than 75% similarity scores to characterized clusters within the MIBiG database are presented. This survey provides the biosynthetic diversity of these BGCs and an assessment of the predicted chemical space yet to be discovered. Considering the mere snapshot of myxobacteria included in this analysis, these untapped BGCs exemplify the potential for natural product discovery from myxobacteria.
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Created Date:
2019 06 01 T07:00:00 Z
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